Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24557359 | 0.85 | APP (0.49) | MEN1KMT2AAPPHDAC4HDAC8 | |
| SCHEMBL18469822 | 0.79 | ACHE (0.39) | MEN1KMT2AAPPALDH1A1SMN1; SMN2 | |
| SCHEMBL18857351 | 0.79 | MEN1 (0.45) | MEN1KMT2AHDAC4HDAC8ALDH1A1 | |
| SCHEMBL21726732 | 0.78 | ALDH1A1 (0.50) | MEN1KMT2AHDAC4HDAC8ALDH1A1 | |
| SCHEMBL13947630 | 0.78 | KMT2A (0.57) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL84033 | 0.77 | PPARG (0.53) | KMT2AHDAC4HDAC8ALDH1A1HPGD | |
| SCHEMBL15800483 | 0.76 | HDAC4 (0.47) | MEN1KMT2AHDAC4HDAC8ALDH1A1 | |
| SCHEMBL26386538 | 0.76 | APP (0.51) | MEN1KMT2AAPPCA1CA2 | |
| SCHEMBL8940819 | 0.75 | HDAC4 (0.50) | MEN1KMT2AHDAC4HDAC8ALDH1A1 | |
| SCHEMBL20987638 | 0.74 | LMNA (0.54) | MEN1KMT2AALDH1A1SMN1; SMN2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072301-A1 | PYRAZOLO[3,4-D]PYRIMIDIN-3-ONE COMPOUND AND MEDICAL USE THEREOF | 正大天晴药业集团股份有限公司 | 2023-05-04 | — | — | WO | disclosed |
| US-20190135835-A1 | MK2 INHIBITORS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2019-05-09 | — | — | US | disclosed |
| CN-108341812-A | A kind of preparation method containing quinuclidine compounds | 科贝源(北京)生物医药科技有限公司 | 2018-07-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190135835-A1 | MK2 INHIBITORS AND USES THEREOF | MKNK2, DUSP2, MKNK1 | MEN1 2025/4885KMT2A 377/4885APP 4646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.