Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | IDE | P14735 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20988323 | 0.86 | HPGD (0.71) | MAPK1LMNAMAPTTLR7IDE | |
| SCHEMBL2546011 | 0.84 | ALDH1A1 (0.73) | MAPK1LMNAMAPTTLR7NR1H4 | |
| SCHEMBL20988413 | 0.83 | HDAC1 (0.68) | LMNAMAPTTLR7HPGDALDH1A1 | |
| SCHEMBL15896523 | 0.82 | MAPK1 (0.60) | MAPK1LMNAMAPTTLR7NR1H4 | |
| SCHEMBL20988338 | 0.82 | TLR7 (0.63) | LMNAMAPTTLR7HPGDALDH1A1 | |
| SCHEMBL3533598 | 0.80 | ALDH1A1 (0.65) | MAPK1LMNAMAPTTLR7NR1H4 | |
| SCHEMBL27966345 | 0.80 | MAPK1 (0.59) | MAPK1LMNAMAPTTLR7NR1H4 | |
| SCHEMBL3063332 | 0.79 | LMNA (0.64) | MAPK1LMNAMAPTTLR7NR1H4 | |
| SCHEMBL20988414 | 0.79 | MAPK1 (0.60) | MAPK1LMNAMAPTTLR7NR1H4 | |
| SCHEMBL15893970 | 0.78 | MAPK1 (0.56) | MAPK1LMNAMAPTTLR7NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654802-B2 | Indoline derivatives and method for using and producing the same | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNVERSIT (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190135746-A1 | INDOLINE DERIVATIVES AND METHOD FOR USING AND PRODUCING THE SAME | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNVERSITY OF ARIZONA | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654802-B2 | Indoline derivatives and method for using and producing the same | IDO1, IDO2, MMP1 | MAPK1 2548/4885LMNA 1162/4885MAPT 1971/4885 |
| US-20190135746-A1 | INDOLINE DERIVATIVES AND METHOD FOR USING AND PRODUCING THE SAME | IDO1, INMT, MMP1 | MAPK1 2676/4885LMNA 1099/4885MAPT 1638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.