Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.48 |
| ▸ | RAD51 | Q06609 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 3/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20997500 | 0.82 | TRPV4 (0.44) | CA2RAD51TRPV4CA1 | |
| SCHEMBL20997498 | 0.81 | ELANE (0.43) | CA2RAD51CYP11B1CYP11B2ELANE | |
| SCHEMBL124134 | 0.79 | RAD51 (0.47) | CA2RAD51CYP11B1CYP11B2ELANE | |
| SCHEMBL1755156 | 0.78 | RAD51 (0.44) | CA2RAD51TRPV4CA1 | |
| SCHEMBL9877386 | 0.78 | CA2 (0.54) | CA2CA1 | |
| SCHEMBL9558916 | 0.77 | CA2 (0.61) | CA2 | |
| SCHEMBL3778124 | 0.76 | CA1 (0.47) | CA2RAD51TRPV4PTGES2STS | |
| SCHEMBL8255487 | 0.75 | RAD51 (0.44) | CA2RAD51TRPV4EPAS1STS | |
| SCHEMBL1014212 | 0.73 | CA2 (0.58) | CA2CA1 | |
| SCHEMBL9877593 | 0.72 | CA2 (0.51) | CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174862-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2019-10-23 | — | — | EP | disclosed |
| EP-3174861-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2019-05-15 | — | — | EP | disclosed |