Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.37 |
| ▸ | SGK1 | O00141 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15932447 | 0.83 | TRPV4 (0.45) | ELANEKCNJ6KCNJ5KCNJ3RAD51 | |
| SCHEMBL20997497 | 0.81 | CA2 (0.48) | ELANERAD51TRPV4CYP11B1CYP11B2 | |
| SCHEMBL124134 | 0.79 | RAD51 (0.47) | ELANERAD51TRPV4CYP11B1CYP11B2 | |
| SCHEMBL13093638 | 0.78 | RAD51 (0.44) | KCNJ6KCNJ5KCNJ3RAD51TRPV4 | |
| SCHEMBL3650210 | 0.77 | ALDH1A1 (0.45) | CA2ALDH1A1 | |
| SCHEMBL125367 | 0.76 | RAD51 (0.45) | ELANEKCNJ6KCNJ5KCNJ3RAD51 | |
| SCHEMBL9498840 | 0.76 | CA2 (0.47) | CA2ALDH1A1 | |
| SCHEMBL31263607 | 0.76 | CA2 (0.47) | CA2ALDH1A1 | |
| SCHEMBL22867349 | 0.75 | CA1 (0.46) | KCNJ6KCNJ5KCNJ3RAD51CA2 | |
| SCHEMBL3079216 | 0.75 | TRPV4 (0.54) | KCNJ6KCNJ5KCNJ3RAD51TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174861-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2019-05-15 | — | — | EP | disclosed |