Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23897448 | 0.91 | SDHB (0.40) | SDHBKMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL21019829 | 0.84 | SDHB (0.40) | SDHBKMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL21020109 | 0.84 | SDHB (0.40) | SDHBKMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL21019734 | 0.74 | SDHB (0.56) | SDHBKMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL21019517 | 0.74 | SDHB (0.54) | SDHBKMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL19805646 | 0.74 | SDHB (0.71) | SDHB | |
| SCHEMBL29976514 | 0.74 | SDHB (0.71) | SDHB | |
| SCHEMBL21020592 | 0.73 | SDHB (0.49) | SDHBKMT2ASMN1; SMN2LMNATP53 | |
| SCHEMBL28306297 | 0.73 | ACHE (0.39) | SDHBKMT2ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL21019460 | 0.73 | SDHB (0.50) | SDHBKMT2ASMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034680-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20190152960-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152960-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | SDHB 3/4885KMT2A 3060/4885SMN1; SMN2 1698/4885 |
| US-11034680-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | SDHB 3/4885KMT2A 3060/4885SMN1; SMN2 1698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.