Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12331017 | 0.89 | HDAC8 (0.57) | HDAC8HDAC6NPC1RAB9AATM | |
| SCHEMBL12678023 | 0.85 | MAPK14 (0.57) | HDAC8HDAC6NPC1RAB9AATM | |
| SCHEMBL18971666 | 0.84 | ATM (0.59) | HDAC8HDAC6NPC1RAB9AATM | |
| SCHEMBL3655101 | 0.83 | KDM4E (0.59) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL18944083 | 0.83 | HDAC8 (0.51) | HDAC8HDAC6NPC1RAB9AATM | |
| SCHEMBL20206540 | 0.82 | ACHE (0.55) | HDAC8HDAC6RAB9ASMN1; SMN2POLB | |
| SCHEMBL18175984 | 0.82 | KDM4E (0.54) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL29836705 | 0.82 | L3MBTL1 (0.67) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL1360195 | 0.81 | HDAC8 (0.65) | HDAC8HDAC6NPC1RAB9AATM | |
| SCHEMBL10605827 | 0.81 | HDAC8 (0.65) | HDAC8HDAC6NPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151289-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) Histone Demethylase | UNIV YALE (US) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151289-A1 | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) Histone Demethylase | KDM1A, KDM1B, JMJD1C | HDAC8 168/4885HDAC6 610/4885NPC1 4419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.