Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20809000 | 0.84 | MAPT (0.58) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20786880 | 0.82 | MCL1 (0.53) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL12838812 | 0.79 | KDM4E (0.67) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21025153 | 0.78 | KDM4E (0.47) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22393621 | 0.77 | MEN1 (0.48) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21025561 | 0.75 | MEN1 (0.47) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL19392441 | 0.74 | MAPT (0.60) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25111597 | 0.73 | L3MBTL1 (0.46) | KMT2AMAPTMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21025346 | 0.71 | RAB9A (0.47) | POLBBTK | |
| SCHEMBL2611241 | 0.71 | HDAC6 (0.66) | KMT2AMAPTMEN1SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669252-B2 | Benzazepine derivative, preparation method, pharmaceutical composition and use thereof | Shanghai De Novo Pharmatech Co., Ltd. (CN) | 2020-06-02 | — | — | US | disclosed |
| US-20190152941-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai De Novo Pharmatech Co., Ltd. (CN) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10669252-B2 | Benzazepine derivative, preparation method, pharmaceutical composition and use thereof | TLR8, TLR1, TLR5 | KMT2A 751/4885MAPT 4056/4885MEN1 2449/4885 |
| US-20190152941-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | TLR8, TLR1, TLR5 | KMT2A 751/4885MAPT 4056/4885MEN1 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.