Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21025968 | 0.89 | CRHR1 (0.42) | CRHR1CNR2KCNH2IRAK4CRHR2 | |
| SCHEMBL17678027 | 0.81 | CRHR1 (0.38) | CRHR1IRAK4KDM2BPIK3CDPIK3CA | |
| SCHEMBL19279762 | 0.78 | HTR7 (0.38) | CRHR1IRAK4KDM2BPIK3CDPIK3CA | |
| SCHEMBL3389492 | 0.78 | ALDH1A1 (0.50) | CRHR1KCNH2HRH3PIK3CDPIK3CA | |
| SCHEMBL30995477 | 0.78 | CRHR1 (0.42) | CRHR1HRH3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL21026068 | 0.74 | IRAK4 (0.41) | CNR2KCNH2IRAK4F2RL3 | |
| SCHEMBL28217862 | 0.73 | CRHR1 (0.50) | CRHR1KDM2BPIK3CDPIK3CAPIK3CB | |
| SCHEMBL13432210 | 0.72 | CRHR1 (0.38) | CRHR1IRAK4KDM2BPIK3CDPIK3CA | |
| SCHEMBL12319284 | 0.72 | MAPT (0.58) | KCNH2HRH4HRH3SCN10AF2RL3 | |
| SCHEMBL5137202 | 0.71 | NPC1 (0.39) | CRHR1KCNH2KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151312-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151312-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | HPSE, GAA, MAN2B1 | CRHR1 2178/4885CNR2 3059/4885KCNH2 4772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.