Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 6/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.30 |
| ▸ | VEGFA | P15692 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3744381 | 1.00 | POLB (0.34) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18472040 | 1.00 | POLB (0.34) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27358271 | 0.82 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL792893 | 0.82 | ITGB1 (0.32) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL31441632 | 0.82 | ITGB1 (0.32) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL4474074 | 0.81 | TDP1 (0.35) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18725504 | 0.80 | ATM (0.36) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL12414703 | 0.79 | TSHR (0.36) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL12414701 | 0.79 | TSHR (0.36) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL630437 | 0.79 | CRBN (0.44) | POLBTSHRCHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348457-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230348457-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230295151-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2023-09-21 | — | — | US | disclosed |
| US-20230295151-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2023-09-21 | — | — | US | disclosed |
| US-11685735-B2 | Pharmaceutical composition comprising berberine salts for the treatment of various diseases or disorders | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2023-06-27 | — | — | US | disclosed |
| US-11685735-B2 | Pharmaceutical composition comprising berberine salts for the treatment of various diseases or disorders | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2023-06-27 | — | — | US | disclosed |
| CN-110551052-A | Preparation method of (R) -4-hydroxy-2-oxo-1-pyrrolidine acetate | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | disclosed |
| CN-110551053-A | preparation method of dextro-oxypyr-mepyramine | CHONGQING RUNZE PHARMACEUTICAL | 2019-12-10 | — | — | CN | disclosed |
| US-10301303-B2 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2019-05-28 | — | — | US | disclosed |
| CN-109251157-A | (R)-Esomeprazole preparation method | 重庆润泽医药有限公司 | 2019-01-22 | — | — | CN | disclosed |
| CN-109251157-A | (R)-Esomeprazole preparation method | 重庆润泽医药有限公司 | 2019-01-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348457-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | POLB 2698/4885PDE4A 3707/4885PDE4B 4091/4885 |
| US-11685735-B2 | Pharmaceutical composition comprising berberine salts for the treatment of various diseases or disorders | CPT1B, CYP27A1, GLS2 | POLB 2519/4885PDE4A 3342/4885PDE4B 3655/4885 |
| US-20230295151-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | POLB 2698/4885PDE4A 3707/4885PDE4B 4091/4885 |
| US-10301303-B2 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof | CYP27A1, NR1H4, CYP7A1 | POLB 2698/4885PDE4A 3707/4885PDE4B 4091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.