Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 6/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.30 |
| ▸ | VEGFA | P15692 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21026696 | 1.00 | POLB (0.34) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18472040 | 1.00 | POLB (0.34) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27358271 | 0.82 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL792893 | 0.82 | ITGB1 (0.32) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL31441632 | 0.82 | ITGB1 (0.32) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL4474074 | 0.81 | TDP1 (0.35) | POLBCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18725504 | 0.80 | ATM (0.36) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL12414703 | 0.79 | TSHR (0.36) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL12414701 | 0.79 | TSHR (0.36) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL630437 | 0.79 | CRBN (0.44) | POLBTSHRCHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1268611-C | Method of preparing 4-hydroxy pyrrolidone-2-acetamine | ZHANGJIAGANG HAOBO CHEMICALS C (CN) | 2006-08-09 | — | — | CN | claimed |
| CN-1513836-A | Method of preparing 4-hydroxy pyrrolidone-2-acetamine | 张家港浩波化学品有限公司 | 2004-07-21 | — | — | CN | claimed |
| EP-0207681-A2 | Pyrrolidone derivatives | ISF SOCIETA PER AZIONI (IT) | 1987-01-07 | — | — | EP | claimed |
| CN-115466251-B | Condensed heterocyclic compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-06-21 | — | — | CN | disclosed |
| CN-115466251-A | Fused heterocyclic compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-12-13 | — | — | CN | disclosed |
| US-20210300915-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2021-09-30 | — | — | US | disclosed |
| US-10988471-B2 | Pharmaceutical composition comprising berberine ursodeoxycholic acid salt for the treatment of various diseases or disorders | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2021-04-27 | — | — | US | disclosed |
| US-20190211007-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
| CN-104447730-A | Oxazolidinone compounds and application thereof to drugs | GUANGDONG HEC PHARMACEUTICAL | 2015-03-25 | — | — | CN | disclosed |
| CN-104387376-A | Pyridone compound as well as composition and applications thereof | GUANGDONG HEC PHARMACEUTICAL | 2015-03-04 | — | — | CN | disclosed |
| US-8242285-B2 | N-tert-butoxycarbonyl-2-pyrrolidinones and production method thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-14 | — | — | US | disclosed |
| EP-2008999-A1 | N-TERT-BUTOXYCARBONYL-2-PYRROLIDINONES AND PROCESS FOR PRODUCING THE SAME | Sumitomo Chemical Company, Limited (JP) | 2008-12-31 | — | — | EP | disclosed |
| CN-101296902-A | Compounds comprising lactam or lactam derivative moieties, processes for preparing them and their use | UCB PHARMA SA (BE) | 2008-10-29 | — | — | CN | disclosed |
| CN-1268611-C | Method of preparing 4-hydroxy pyrrolidone-2-acetamine | ZHANGJIAGANG HAOBO CHEMICALS C (CN) | 2006-08-09 | — | — | CN | disclosed |
| CN-1513836-A | Method of preparing 4-hydroxy pyrrolidone-2-acetamine | 张家港浩波化学品有限公司 | 2004-07-21 | — | — | CN | disclosed |
| CN-1216522-A | Therapeutic agent for diabetes | JAPAN TOBACCO INC (JP) | 1999-05-12 | — | — | CN | disclosed |
| US-5371237-A | Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide | LONZA LTD. (CH) | 1994-12-06 | — | — | US | disclosed |
| US-5276164-A | Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide | LONZA LTD. (CH) | 1994-01-04 | — | — | US | disclosed |
| EP-0207680-A2 | Chemical compounds | ISF SOCIETA PER AZIONI (IT) | 1987-01-07 | — | — | EP | disclosed |
| US-4369139-A | PREVENTION OF CEREBRAL INSUFFICIENCY | HOFFMANN-LA ROCHE INC. (US) | 1983-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190211007-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | POLB 2698/4885PDE4A 3707/4885PDE4B 4091/4885 |
| US-10988471-B2 | Pharmaceutical composition comprising berberine ursodeoxycholic acid salt for the treatment of various diseases or disorders | CYP27A1, SLC10A1, NR1H4 | POLB 2990/4885PDE4A 3586/4885PDE4B 3932/4885 |
| US-20210300915-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | POLB 2698/4885PDE4A 3707/4885PDE4B 4091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.