Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11564854 | 0.71 | TRPM8 (0.44) | CSF1REGFRLMNATP53ALDH1A1 | |
| SCHEMBL13663832 | 0.69 | MEN1 (0.44) | LMNAALDH1A1 | |
| SCHEMBL11564050 | 0.62 | LMNA (0.43) | CSF1REGFRLMNATP53ALDH1A1 | |
| SCHEMBL22360336 | 0.58 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL13530809 | 0.57 | CSF1R (0.40) | CSF1REGFRLMNATP53ALDH1A1 | |
| SCHEMBL15079442 | 0.57 | CYP2C19 (0.52) | ALDH1A1 | |
| SCHEMBL4402952 | 0.57 | CYP2C19 (0.52) | ALDH1A1 | |
| SCHEMBL11563487 | 0.55 | CSF1R (0.43) | CSF1REGFRLMNATP53ALDH1A1 | |
| SCHEMBL11568099 | 0.55 | KDM4E (0.41) | LMNAALDH1A1 | |
| SCHEMBL21209779 | 0.55 | MAPT (0.52) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489238-A1 | PHARMACEUTICAL COMPOSITIONS OF 6H-PYRIDO[3,2-E][1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-5-ONE AND [1,2,4]TRIAZOLO[1,5-C]PTERIDIN-5(6H)-ONE DERIVATIVES AS PDE1 INHIBITORS FOR TREATING E.G. NEUROLOGICAL DISORDERS | Dart NeuroScience (Cayman) Ltd (KY) | 2019-05-29 | — | — | EP | disclosed |