Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15061930 | 0.74 | NOS3 (0.40) | TRPM8LMNATP53HTTMEN1 | |
| SCHEMBL11564050 | 0.71 | LMNA (0.43) | CSF1REGFRLMNATP53NPSR1 | |
| SCHEMBL21029480 | 0.71 | CSF1R (0.36) | CSF1REGFRLMNATP53BRD4 | |
| SCHEMBL2129213 | 0.70 | NR1H4 (0.50) | TRPM8CSF1REGFRNR1H4 | |
| SCHEMBL11568099 | 0.70 | KDM4E (0.41) | LMNANPSR1PYCR1HTTSMN1; SMN2 | |
| SCHEMBL17532955 | 0.69 | PGK1 (0.39) | TRPM8LMNATP53NPSR1HTT | |
| SCHEMBL16158780 | 0.68 | GLP1R (0.41) | TRPM8LMNANPSR1HTTKMT2A | |
| SCHEMBL11564873 | 0.67 | ALDH1A1 (0.46) | LMNATP53BRD4HTTSMN1; SMN2 | |
| SCHEMBL13530809 | 0.66 | CSF1R (0.40) | CSF1REGFRLMNATP53HSP90AA1 | |
| SCHEMBL15079442 | 0.66 | CYP2C19 (0.52) | PYCR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000816-A1 | Substituted amino-pyridine derivatives, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1979-02-21 | — | — | EP | disclosed |