Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.75 |
| ▸ | ENPP1 | P22413 | 6/20 | 0.63 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.63 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.63 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | DTYMK | P23919 | 2/20 | 0.52 |
| ▸ | NT5E | P21589 | 3/20 | 0.52 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21029886 | 0.90 | POLB (0.61) | POLBENPP1P2RX3P2RX1P2RY1 | |
| SCHEMBL14330856 | 0.82 | TRPM2 (0.62) | POLBENPP1P2RX3P2RX1P2RY1 | |
| SCHEMBL8921016 | 0.79 | ADORA2A (0.52) | POLBLMNAADORA1PDE4DPDE3A | |
| Diphosphomethylphosphonic Acid Adenosyl Ester SCHEMBL2345274 | 0.78 | ENPP1 (1.00) | POLBENPP1P2RX3P2RX1P2RY1 | |
| Diphosphomethylphosphonic Acid Adenosyl Ester SCHEMBL29428268 | 0.78 | ENPP1 (1.00) | POLBENPP1P2RX3P2RX1P2RY1 | |
| SCHEMBL22887211 | 0.77 | P2RX3 (0.55) | POLBP2RX3P2RX1P2RY1ALDH1A1 | |
| SCHEMBL20879494 | 0.76 | P2RX3 (0.55) | P2RX3P2RX1P2RY1ALDH1A1TRPM2 | |
| SCHEMBL18840499 | 0.76 | P2RX3 (0.57) | P2RX3P2RX1P2RY1ALDH1A1TRPM2 | |
| SCHEMBL21030881 | 0.76 | POLB (0.73) | POLBENPP1P2RX3P2RX1P2RY1 | |
| SCHEMBL21362895 | 0.75 | ENPP1 (0.74) | POLBENPP1P2RX3P2RX1P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019104316-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING AND/OR PREVENTING PERIODONTAL DISEASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-05-31 | — | — | WO | disclosed |