Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103584 | 0.81 | ABCB11 (0.42) | MAPTHTTNPSR1HPGDCYP1A2 | |
| SCHEMBL2099802 | 0.81 | TSHR (0.69) | TSHRHTR2AHTR2CHTR2BSMN1; SMN2 | |
| SCHEMBL3345930 | 0.81 | TSHR (0.69) | TSHRHTR2AHTR2CHTR2BSMN1; SMN2 | |
| SCHEMBL21094904 | 0.79 | SMN1; SMN2 (0.44) | TSHRHTR2AHTR2CHTR2BSMN1; SMN2 | |
| SCHEMBL2099452 | 0.75 | AAK1 (0.43) | TSHRHTR2AHTR2CHTR2BSMN1; SMN2 | |
| SCHEMBL11238875 | 0.75 | TSHR (0.43) | TSHRHTR2AHTR2CHTR2BSMN1; SMN2 | |
| SCHEMBL2104209 | 0.74 | TSHR (0.46) | TSHRHTR2AHTR2CHTR2BSMN1; SMN2 | |
| SCHEMBL1359818 | 0.73 | APP (0.46) | SMN1; SMN2LMNAMAPTCYP1A2CYP3A4 | |
| SCHEMBL2100681 | 0.73 | ABCB11 (0.47) | TSHRHTR2AHTR2CHTR2BSMN1; SMN2 | |
| SCHEMBL2282240 | 0.72 | SLC6A9 (0.37) | TSHRHTR2AHTR2CHTR2BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163727-B2 | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |