Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 14/20 | 0.48 |
| ▸ | RORA | P35398 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RORB | Q92753 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21031874 | 0.89 | PTGDR2 (0.45) | PTGDR2RORARORCRORBHTR6 | |
| SCHEMBL21032881 | 0.87 | PTGDR2 (0.45) | PTGDR2 | |
| SCHEMBL21032723 | 0.87 | PTGDR2 (0.66) | PTGDR2PTGS1AKR1B1 | |
| SCHEMBL21032545 | 0.80 | MAPT (0.39) | PTGDR2TP53MAPTPTGS1 | |
| SCHEMBL21032469 | 0.79 | PTGDR2 (0.60) | PTGDR2AKR1B1 | |
| SCHEMBL21031868 | 0.79 | PTGDR2 (0.66) | PTGDR2PTGS1AKR1A1AKR1B1 | |
| SCHEMBL21032209 | 0.77 | PTGDR2 (0.61) | PTGDR2PTGS1 | |
| SCHEMBL24180002 | 0.75 | PTGDR2 (0.45) | PTGDR2PTGS1AKR1B1 | |
| SCHEMBL21032707 | 0.72 | MAPK14 (0.43) | PTGDR2MAPT | |
| SCHEMBL21032706 | 0.71 | PTGDR2 (0.36) | PTGDR2HTR6MAPTAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489233-B1 | INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2022-01-12 | — | — | EP | disclosed |
| EP-3489233-A1 | INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-05-29 | — | — | EP | disclosed |