Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21032707 | 0.86 | MAPK14 (0.43) | PTGDR2KDM4EMAPTMAPK1L3MBTL1 | |
| SCHEMBL21032411 | 0.81 | HTR6 (0.46) | PTGDR2AKR1B1HTR6KDM4EMAPT | |
| SCHEMBL21032545 | 0.76 | MAPT (0.39) | PTGDR2KDM4EMAPTMAPK1L3MBTL1 | |
| SCHEMBL21031874 | 0.76 | PTGDR2 (0.45) | PTGDR2HTR6MAPTL3MBTL1CYP2C9 | |
| SCHEMBL21032561 | 0.75 | PTGDR2 (0.59) | PTGDR2AKR1B1CYP2C9PTGDR | |
| SCHEMBL21031949 | 0.74 | PTGDR2 (0.52) | PTGDR2CYP2C9PTGDR | |
| SCHEMBL21032881 | 0.73 | PTGDR2 (0.45) | PTGDR2METAP2 | |
| SCHEMBL24179971 | 0.72 | METAP2 (0.39) | PTGDR2METAP2 | |
| SCHEMBL21032472 | 0.71 | PTGDR2 (0.48) | PTGDR2AKR1B1HTR6MAPT | |
| SCHEMBL24180030 | 0.71 | PTGDR2 (0.50) | PTGDR2CYP2C9PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489233-B1 | INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2022-01-12 | — | — | EP | disclosed |
| EP-3489233-A1 | INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-05-29 | — | — | EP | disclosed |