Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 6/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21031949 | 0.87 | PTGDR2 (0.52) | PTGDR2 | |
| SCHEMBL21032706 | 0.86 | PTGDR2 (0.36) | METAP2PTGDR2KDM4EMAPTMAPK1 | |
| SCHEMBL21032545 | 0.78 | MAPT (0.39) | PTGDR2KDM4EMAPTMAPK1L3MBTL1 | |
| SCHEMBL24179971 | 0.77 | METAP2 (0.39) | METAP2PTGDR2 | |
| SCHEMBL21032556 | 0.76 | PTGDR2 (0.53) | PTGDR2 | |
| SCHEMBL21032411 | 0.76 | HTR6 (0.46) | PTGDR2KDM4EMAPTMAPK1L3MBTL1 | |
| SCHEMBL21032881 | 0.74 | PTGDR2 (0.45) | METAP2PTGDR2KMT2AALDH1A1 | |
| SCHEMBL24180030 | 0.74 | PTGDR2 (0.50) | PTGDR2 | |
| SCHEMBL21032554 | 0.73 | PTGDR2 (0.49) | PTGDR2 | |
| SCHEMBL21032472 | 0.72 | PTGDR2 (0.48) | PTGDR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489233-B1 | INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2022-01-12 | — | — | EP | disclosed |
| EP-3489233-A1 | INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-05-29 | — | — | EP | disclosed |