Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 3/20 | 0.31 |
| ▸ | FAP | Q12884 | 3/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033308 | 0.84 | HTR6 (0.41) | HTR6PTGS2TYK2KMT2ALMNA | |
| SCHEMBL21001663 | 0.80 | KDM4E (0.45) | HTR6PTGS2TYK2PDE2AKMT2A | |
| SCHEMBL18122086 | 0.73 | HTR6 (0.43) | HTR6PTGS2TYK2DPP4FAP | |
| SCHEMBL17883350 | 0.70 | HTR6 (0.38) | HTR6PTGS2TYK2LMNAPKM | |
| SCHEMBL8353834 | 0.69 | ADORA3 (0.40) | PTGS2LMNAPTGS1KDM4ECYP1A2 | |
| SCHEMBL24066067 | 0.66 | HTR6 (0.36) | HTR6PTGS2TYK2PDE2A | |
| SCHEMBL18208948 | 0.65 | POLB (0.42) | HTR6PTGS2KMT2ALMNAPKM | |
| SCHEMBL23013906 | 0.64 | HTT (0.43) | KMT2ALMNAMEN1KDM4ECYP1A2 | |
| SCHEMBL21033227 | 0.64 | TGFBR1 (0.35) | KMT2ALMNADPP4FAPDPP8 | |
| SCHEMBL4940329 | 0.64 | NTRK1 (0.42) | HTR6PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019102494-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | JUBILANT BIOSYS LIMITED (IN) | 2019-05-31 | — | — | WO | disclosed |