Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21034430 | 0.83 | ALDH1A1 (0.39) | ALDH1A1LMNASLC15A2PAOXGAA | |
| SCHEMBL11918240 | 0.81 | ALDH1A1 (0.47) | ALDH1A1LMNASLC15A2PAOXGAA | |
| SCHEMBL3293803 | 0.81 | LMNA (0.38) | ALDH1A1LMNAALOX15BLMPMP22 | |
| Hydrochloric Acid SCHEMBL6214815 | 0.79 | LMNA (0.36) | ALDH1A1LMNAALOX15BLMPMP22 | |
| SCHEMBL2612046 | 0.79 | ALDH1A1 (0.45) | ALDH1A1LMNASLC15A2GAATDP1 | |
| SCHEMBL27669499 | 0.79 | ALDH1A1 (0.46) | ALDH1A1LMNASLC15A2BLMPMP22 | |
| SCHEMBL23393881 | 0.77 | LMNA (0.30) | LMNAHSD17B10 | |
| SCHEMBL9842065 | 0.76 | LMNA (0.37) | ALDH1A1LMNAALOX15BLMPMP22 | |
| SCHEMBL23905225 | 0.75 | TDP1 (0.32) | ALDH1A1TDP1CYP1A2 | |
| SCHEMBL31016295 | 0.75 | ALDH1A1 (0.41) | ALDH1A1LMNASLC15A2PAOXGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555769-B1 | METHODS FOR TREATING RESPIRATORY VIRAL INFECTION | AMGEN EUROPE GMBH (CH) | 2022-01-12 | — | — | EP | disclosed |
| EP-3904875-A1 | METHODS FOR DETERMINING DRUG EFFICACY USING IKZF3 (AIOLOS) | Celgene Corporation (US) | 2021-11-03 | — | — | EP | disclosed |
| EP-3489682-B1 | METHODS FOR DETERMINING DRUG EFFICACY USING IKZF3 (AIOLOS) | CELGENE CORP (US) | 2021-03-31 | — | — | EP | disclosed |
| EP-3489682-A1 | METHODS FOR DETERMINING DRUG EFFICACY USING IKZF3 (AIOLOS) | Celgene Corporation (US) | 2019-05-29 | — | — | EP | disclosed |