Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21035141 | 0.83 | ALDH1A1 (0.45) | ALDH1A1TDP1LMNAPAOXSLC15A2 | |
| SCHEMBL20663500 | 0.81 | — | — | |
| SCHEMBL11918240 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TDP1LMNAPAOXSLC15A2 | |
| SCHEMBL2612046 | 0.73 | ALDH1A1 (0.45) | ALDH1A1TDP1LMNASLC15A2GAA | |
| SCHEMBL23905225 | 0.70 | TDP1 (0.32) | ALDH1A1TDP1 | |
| SCHEMBL681141 | 0.69 | — | — | |
| SCHEMBL12640188 | 0.69 | ALDH1A1 (0.53) | ALDH1A1TDP1LMNAPAOXSLC15A2 | |
| SCHEMBL5911694 | 0.68 | ALDH1A1 (0.39) | ALDH1A1LMNASLC15A2GAA | |
| SCHEMBL21943798 | 0.68 | ACLY (0.32) | — | |
| SCHEMBL11913941 | 0.68 | CYP1A2 (0.41) | ALDH1A1TDP1LMNASLC15A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3904875-A1 | METHODS FOR DETERMINING DRUG EFFICACY USING IKZF3 (AIOLOS) | Celgene Corporation (US) | 2021-11-03 | — | — | EP | disclosed |
| EP-3489682-A1 | METHODS FOR DETERMINING DRUG EFFICACY USING IKZF3 (AIOLOS) | Celgene Corporation (US) | 2019-05-29 | — | — | EP | disclosed |