SCHEMBL21035323

SCHEMBL21035323

COC(=O)[C@@H]1CN(C(c2ccc(C(F)(F)F)cc2)c2ccc(C(F)(F)F)cc2)CCN1S(=O)(=O)c1ccc(OCC2CCCCC2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 3/20 0.43
HCRTR2 O43614 3/20 0.43
MMP1 P03956 5/20 0.43
ADAM17 P78536 2/20 0.43
KCNQ1 P51787 1/20 0.42
KMT2A Q03164 2/20 0.42
ALDH1A1 P00352 1/20 0.42
MMP3 P08254 4/20 0.41
MMP7 P09237 3/20 0.41
MMP13 P45452 3/20 0.41
MMP9 P14780 2/20 0.40
CCR3 P51677 2/20 0.39
BRD4 O60885 1/20 0.39
CACNA1A O00555 1/20 0.39
CACNA2D1 P54289 1/20 0.39
CACNB1 Q02641 1/20 0.39
HSD11B1 P28845 1/20 0.38
MAPT P10636 1/20 0.38
ITGB1 P05556 1/20 0.38
ITGA4 P13612 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21035063 0.97 CACNA1A (0.44) HCRTR1HCRTR2MMP1ADAM17KCNQ1
SCHEMBL21035451 0.92 HCRTR1 (0.41) HCRTR1HCRTR2MMP1ADAM17KCNQ1
SCHEMBL21036250 0.92 HCRTR1 (0.41) HCRTR1HCRTR2MMP1ADAM17KCNQ1
SCHEMBL21035366 0.92 HCRTR1 (0.41) HCRTR1HCRTR2MMP1ADAM17KCNQ1
SCHEMBL21035326 0.91 MMP1 (0.42) HCRTR1HCRTR2MMP1ADAM17KCNQ1
SCHEMBL21035356 0.89 LMNA (0.48) MMP1KMT2AALDH1A1MMP3MMP7
SCHEMBL21035573 0.89 LMNA (0.48) MMP1KMT2AALDH1A1MMP3MMP7
SCHEMBL21035064 0.89 LMNA (0.45) HCRTR1HCRTR2MMP1ADAM17KCNQ1
SCHEMBL21035324 0.86 LMNA (0.43) HCRTR1HCRTR2MMP1ADAM17KCNQ1
SCHEMBL21035062 0.84 LMNA (0.48) MMP1ADAM17KMT2AMMP13MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019104011-A1 CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2019-05-31 WO disclosed