Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.55 |
| ▸ | TUBB | P07437 | 8/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.55 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.55 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2605630 | 0.86 | LMNA (0.73) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL8017650 | 0.85 | LMNA (0.61) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL4821171 | 0.83 | TUBB1 (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7368386 | 0.83 | TTR (0.58) | LMNATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1308823 | 0.82 | TUBB4A (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL27595882 | 0.82 | LMNA (0.69) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL30716507 | 0.81 | L3MBTL1 (0.59) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL4108486 | 0.81 | L3MBTL1 (0.59) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL4824442 | 0.79 | TUBB4A (0.60) | LMNATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1308130 | 0.79 | ABCB1 (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| US-20050245518-A1 | Antiproliferative agents | METHYLGENE, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | HDAC1, HDAC11, HDAC5 | LMNA 1962/4885TUBB4A 933/4885TUBB 756/4885 |
| US-20050245518-A1 | Antiproliferative agents | HDAC1, HDAC11, HDAC5 | LMNA 1851/4885TUBB4A 850/4885TUBB 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.