Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13462187 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA3CHRNA4CHRNB4HTR6 | |
| Trifluoroacetic Acid SCHEMBL20523513 | 0.90 | CHRNB2 (0.36) | CHRNB2CHRNA3CHRNA4CHRNB4HTR6 | |
| SCHEMBL28356121 | 0.84 | HTR6 (0.43) | CHRNB2CHRNA3CHRNA4HTR6CHRNB3 | |
| SCHEMBL6903463 | 0.82 | HTR6 (0.39) | HTR6HRH3SMN1; SMN2 | |
| SCHEMBL6840183 | 0.82 | CHRNB2 (0.48) | CHRNB2CHRNA3CHRNA4CHRNB4HTR6 | |
| SCHEMBL8145007 | 0.81 | L3MBTL3 (0.41) | CHRNB2CHRNA3CHRNA4CHRNB4HTR6 | |
| SCHEMBL31209662 | 0.81 | HTR6 (0.43) | CHRNB2CHRNA3CHRNA4CHRNB4HTR6 | |
| SCHEMBL13812392 | 0.81 | HTR6 (0.43) | CHRNB2CHRNA3CHRNA4CHRNB4HTR6 | |
| SCHEMBL31209536 | 0.81 | HTR6 (0.43) | CHRNB2CHRNA3CHRNA4CHRNB4HTR6 | |
| Hydrochloric Acid SCHEMBL6662100 | 0.80 | HTR6 (0.37) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601297-B9 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC (US) | 2023-05-24 | — | — | EP | disclosed |
| US-11224601-B1 | Compounds that inhibits MCL-1 protein | AMGEN INC. (US) | 2022-01-18 | — | — | US | disclosed |
| US-10300075-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2019-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10300075-B2 | Compounds that inhibit MCL-1 protein | MCL1, BCL9, BCL2L1 | CHRNB2 4847/4885CHRNA3 4868/4885CHRNA4 4879/4885 |
| US-11224601-B1 | Compounds that inhibits MCL-1 protein | MCL1, BCL9, BCL2L1 | CHRNB2 4846/4885CHRNA3 4866/4885CHRNA4 4879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.