Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 5/20 | 0.57 |
| ▸ | CPA2 | P48052 | 5/20 | 0.57 |
| ▸ | CPA4 | Q9UI42 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2632695 | 0.88 | CPA1 (0.62) | CPA1CPA2CPA4ALDH1A1MMP1 | |
| SCHEMBL26646315 | 0.85 | MMP1 (0.55) | ALDH1A1MMP1MMP2MMP12MMP13 | |
| SCHEMBL23616270 | 0.84 | SMN1; SMN2 (0.50) | ALDH1A1MMP1MMP2MMP12MMP13 | |
| SCHEMBL2632703 | 0.84 | CPA1 (0.61) | CPA1CPA2CPA4ALDH1A1MMP1 | |
| SCHEMBL17948648 | 0.84 | CPA1 (0.63) | CPA1CPA2CPA4ALDH1A1MMP2 | |
| SCHEMBL23616381 | 0.83 | TSHR (0.65) | ALDH1A1MMP1MMP2MMP12MMP13 | |
| SCHEMBL10078882 | 0.83 | TSHR (0.65) | ALDH1A1MMP1MMP2MMP12MMP13 | |
| SCHEMBL23616296 | 0.83 | CTSS (0.67) | CTSL | |
| SCHEMBL23616295 | 0.83 | CTSS (0.67) | CTSL | |
| SCHEMBL2633272 | 0.82 | CPA1 (0.56) | CPA1CPA2CPA4ALDH1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227312-B1 | A PROCESS FOR PURIFICATION OF CARFILZOMIB | FRESENIUS KABI ONCOLOGY LTD (IN) | 2019-05-29 | — | — | EP | disclosed |