Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | FSHR | P23945 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL213116 | 0.92 | CCKBR (0.37) | MAP4K1PTGER1TSHRFSHRMAPKAPK2 | |
| SCHEMBL210077 | 0.91 | NOTUM (0.36) | NOTUMMAPK1CTSKADORA3ADORA2A | |
| SCHEMBL210644 | 0.90 | NOTUM (0.36) | NOTUMCTSKGCKADORA3ADORA2A | |
| SCHEMBL2723586 | 0.86 | MAP4K1 (0.39) | MAP4K1PTGER1MAPKAPK2MAPT | |
| SCHEMBL212590 | 0.86 | CTSK (0.36) | PTGER1NOTUMCTSKGCKADORA3 | |
| SCHEMBL210694 | 0.85 | NOTUM (0.34) | NOTUMCTSKADORA3ADORA2AADORA1 | |
| SCHEMBL212116 | 0.85 | CTSK (0.36) | NOTUMCTSKADORA3ADORA2AADORA1 | |
| SCHEMBL212341 | 0.84 | CTSK (0.37) | NOTUMCTSKGCKADORA3ADORA2A | |
| SCHEMBL212597 | 0.84 | NOTUM (0.37) | NOTUMMAPK1CTSKGCKADORA3 | |
| SCHEMBL211462 | 0.84 | CTSK (0.36) | NOTUMCTSKADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | claimed |