Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | FSHR | P23945 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210443 | 0.92 | MAP4K1 (0.37) | MAP4K1PTGER1MAPKAPK2TSHRFSHR | |
| SCHEMBL212116 | 0.92 | CTSK (0.36) | CTSKALDH1A1NOTUM | |
| SCHEMBL212590 | 0.91 | CTSK (0.36) | PTGER1CTSKALDH1A1NOTUMGCK | |
| SCHEMBL212341 | 0.88 | CTSK (0.37) | CCKBRCTSKALDH1A1NOTUMGCK | |
| SCHEMBL213515 | 0.87 | CTSK (0.36) | PTGER1MAPKAPK2CTSKALDH1A1NOTUM | |
| SCHEMBL211462 | 0.87 | CTSK (0.36) | CTSKALDH1A1NOTUM | |
| SCHEMBL2723695 | 0.87 | MAP4K1 (0.38) | CCKBRMAP4K1PTGER1MAPKAPK2TSHR | |
| SCHEMBL210644 | 0.86 | NOTUM (0.36) | CTSKALDH1A1NOTUMGCK | |
| SCHEMBL4353508 | 0.85 | CTSK (0.37) | CTSKMAPK1ALDH1A1NOTUMDYRK1A | |
| SCHEMBL210077 | 0.85 | NOTUM (0.36) | CTSKMAPK1ALDH1A1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |