Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714051 | 0.85 | HTT (0.51) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3714050 | 0.85 | HTT (0.51) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1953141 | 0.81 | TAS1R3 (0.51) | ALDH1A1KMT2A | |
| SCHEMBL20544940 | 0.80 | UTS2R (0.51) | — | |
| SCHEMBL26914443 | 0.80 | MAPT (0.47) | ALDH1A1NPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL25385229 | 0.80 | ALDH1A1 (0.52) | ALDH1A1NPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11022273 | 0.79 | ALDH1A1 (0.51) | ALDH1A1NPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3870433 | 0.78 | ACHE (0.81) | ACHESLC6A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3869727 | 0.78 | ACHE (0.81) | ACHESLC6A4ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL20975454 | 0.77 | CNR1 (0.47) | ALDH1A1NPC1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163767-B2 | Heterocyclic Janus Kinase 3 inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-04-24 | — | — | US | disclosed |