SCHEMBL21046174

SCHEMBL21046174

O=C(O)C(c1cccc2c1Cc1ccccc1-2)C(C(=O)O)c1cccc2c1Cc1ccccc1-2

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2B P41595 4/20 0.49
HTR7 P34969 2/20 0.49
NPC1 O15118 2/20 0.49
RAB9A P51151 2/20 0.49
PNMT P11086 1/20 0.47
SRD5A2 P31213 2/20 0.42
DRD2 P14416 2/20 0.40
HSP90AA1 P07900 2/20 0.40
HTR2C P28335 2/20 0.40
SLC1A3 P43003 1/20 0.40
SLC1A2 P43004 1/20 0.40
SLC1A1 P43005 1/20 0.40
ADRA1D P25100 1/20 0.40
HTR2A P28223 1/20 0.40
ADRA1A P35348 1/20 0.40
ADRA1B P35368 1/20 0.40
GSR P00390 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAOA P21397 2/20 0.37
DRD4 P21917 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8197052 0.87 HTR7 (0.47) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL9420910 0.84 NPC1 (0.50) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL21758208 0.84 NPC1 (0.47) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL28431193 0.83 NPC1 (0.46) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL20889365 0.82 NPC1 (0.46) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL19682584 0.82 NPC1 (0.46) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL21443923 0.81 NPC1 (0.48) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL21758219 0.80 NPC1 (0.43) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL21436821 0.80 NPC1 (0.47) HTR2BHTR7NPC1RAB9APNMT
SCHEMBL30533158 0.80 NPC1 (0.47) HTR2BHTR7NPC1RAB9APNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107417819-B Solid catalyst component for olefin polymerization, catalyst and application thereof 北京利和知信科技有限公司 2021-11-16 CN disclosed
US-11136421-B2 Solid catalyst component for use in olefin polymerisation, catalyst, and application thereof BEIJING LIHE TECHNOLOGY LTD (CN) 2021-10-05 US disclosed
US-20200071430-A1 SOLID CATALYST COMPONENT FOR USE IN OLEFIN POLYMERISATION, CATALYST, AND APPLICATION THEREOF BEIJING LIHE TECH LTD (CN) 2020-03-05 US disclosed
US-20190169328-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF RENQIU LIHE TECH LTD (CN) 2019-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190169328-A1 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF COG2, GTF2I, POF1B HTR2B 457/4885HTR7 1925/4885NPC1 578/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.