Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGFR | P43088 | 3/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212323 | 0.93 | MAPT (0.40) | MAPTTP53SMN1; SMN2RORCTHRB | |
| SCHEMBL212350 | 0.89 | MAOB (0.35) | MAPTFOLH1RAB9A | |
| SCHEMBL212147 | 0.85 | MAPT (0.42) | MAPTTP53SMN1; SMN2RORCTHRB | |
| SCHEMBL210625 | 0.83 | MAPT (0.41) | MAPTTP53SMN1; SMN2RORCTHRB | |
| SCHEMBL211523 | 0.81 | CTSK (0.38) | FOLH1RAB9A | |
| SCHEMBL2840754 | 0.81 | CTSK (0.38) | FOLH1RAB9A | |
| SCHEMBL2724891 | 0.80 | MAPT (0.41) | MAPTTP53SMN1; SMN2RORCTHRB | |
| SCHEMBL2724118 | 0.79 | MAPT (0.40) | MAPTTP53SMN1; SMN2RORCTHRB | |
| SCHEMBL212235 | 0.78 | MAPT (0.41) | MAPTTP53SMN1; SMN2RORCTHRB | |
| SCHEMBL212834 | 0.78 | MAPT (0.41) | MAPTTP53SMN1; SMN2RORCTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |