Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626886 | 0.86 | PTK2 (0.37) | GAAHTTLRRK2KDM4EALDH1A1 | |
| SCHEMBL22561920 | 0.75 | KMT2A (0.35) | HTTLRRK2SLC22A12KDM4EALDH1A1 | |
| Dimethyl Sulfone SCHEMBL17258778 | 0.73 | NOS3 (0.46) | GAAHTTKDM4EALDH1A1SCN9A | |
| SCHEMBL17258804 | 0.70 | HCRTR1 (0.40) | GAAHTTKDM4EALDH1A1 | |
| SCHEMBL7215518 | 0.69 | CHRNB2 (0.42) | KDM4EALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL21048910 | 0.69 | PTK2 (0.40) | LRRK2SLC22A12 | |
| SCHEMBL17258736 | 0.69 | PTK2 (0.36) | GAAHTTLRRK2SLC22A12KDM4E | |
| SCHEMBL21928132 | 0.67 | CYP11B1 (0.38) | KDM4EALDH1A1CYP11B1CYP11B2 | |
| SCHEMBL1627549 | 0.67 | PTPN1 (0.36) | GAAHTTKDM4EALDH1A1 | |
| SCHEMBL31652674 | 0.67 | PTPN1 (0.36) | GAAHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |