Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.42 |
| ▸ | MMP2 | P08253 | 6/20 | 0.42 |
| ▸ | MMP9 | P14780 | 6/20 | 0.42 |
| ▸ | MMP8 | P22894 | 6/20 | 0.42 |
| ▸ | MMP13 | P45452 | 6/20 | 0.42 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048820 | 0.79 | CYP19A1 (0.43) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL11542075 | 0.71 | CRHBP (0.68) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL21048922 | 0.70 | EPHX2 (0.36) | LMNAALDH1A1MAPK1NPC1MAPT | |
| SCHEMBL1802673 | 0.69 | CRHBP (0.60) | CRHBPCRHR2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL629033 | 0.64 | CRHBP (0.59) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL15524258 | 0.63 | CRHBP (0.59) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL20380500 | 0.63 | CRHBP (0.59) | CRHBPCRHR2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL28042132 | 0.63 | CRHBP (0.55) | CRHBPCRHR2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL21048871 | 0.63 | KDM4E (0.39) | ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL21794788 | 0.62 | CRHBP (0.51) | MMP1MMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |