Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048871 | 0.91 | KDM4E (0.39) | NPC1RAB9AHPGDKDM4EALDH1A1 | |
| SCHEMBL1230894 | 0.78 | CYP2C9 (0.44) | NPC1RAB9AF2HPGDCYP2C9 | |
| SCHEMBL21048873 | 0.72 | JAK2 (0.46) | NPC1RAB9AKDM4EALDH1A1GAA | |
| SCHEMBL21048923 | 0.71 | PTK2 (0.49) | ALDH1A1LMNA | |
| SCHEMBL21048818 | 0.70 | MMP1 (0.42) | NPC1RAB9AALDH1A1MAPTMAPK1 | |
| SCHEMBL18595669 | 0.66 | BRD4 (0.44) | HPGDCYP2C9KDM4EALDH1A1GAA | |
| SCHEMBL20483300 | 0.66 | ADORA2A (0.46) | NPC1RAB9AGAAMAPTLMNA | |
| SCHEMBL15145602 | 0.66 | MTNR1A (0.45) | CYP2C9 | |
| SCHEMBL15343468 | 0.64 | ADORA3 (0.41) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL18595670 | 0.64 | PSIP1 (0.45) | HPGDCYP2C9KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |