Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 2/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048818 | 0.79 | MMP1 (0.42) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL17258964 | 0.72 | CYP19A1 (0.44) | CYP19A1CRHBPCRHR2CYP1A2CYP3A4 | |
| SCHEMBL17258961 | 0.72 | CYP19A1 (0.44) | CYP19A1CRHBPCRHR2CYP1A2CYP3A4 | |
| SCHEMBL11542075 | 0.72 | CRHBP (0.68) | MMP1MMP2MMP9MMP8MMP13 | |
| SCHEMBL21048923 | 0.70 | PTK2 (0.49) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| Acetic Acid SCHEMBL1627880 | 0.70 | PTK2 (0.43) | SMN1; SMN2 | |
| SCHEMBL12409792 | 0.68 | PTK2 (0.43) | — | |
| SCHEMBL1802673 | 0.67 | CRHBP (0.60) | CRHBPCRHR2CYP2C19ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL21048756 | 0.67 | PTK2 (0.43) | — | |
| SCHEMBL12640632 | 0.66 | CRHBP (0.55) | CYP19A1CRHBPCRHR2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |