Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 8/20 | 0.49 |
| ▸ | JAK2 | O60674 | 6/20 | 0.44 |
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | TYK2 | P29597 | 6/20 | 0.44 |
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048873 | 0.84 | JAK2 (0.46) | PTK2JAK2JAK1TYK2JAK3 | |
| Acetic Acid SCHEMBL1627880 | 0.81 | PTK2 (0.43) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL12409792 | 0.79 | PTK2 (0.43) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL1230899 | 0.78 | PTK2 (0.55) | PTK2SRPK2SRPK1 | |
| Hydrochloric Acid SCHEMBL21048756 | 0.77 | PTK2 (0.43) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL21048880 | 0.75 | ALDH1A1 (0.48) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL21048922 | 0.71 | EPHX2 (0.36) | ALDH1A1LMNA | |
| SCHEMBL17258893 | 0.69 | ALDH1A1 (0.53) | PTK2JAK2ALDH1A1MEN1KMT2A | |
| SCHEMBL21048871 | 0.68 | KDM4E (0.39) | ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL21048789 | 0.68 | JAK2 (0.43) | PTK2JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |