Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258959 | 0.83 | ALDH1A1 (0.36) | KDM4EALDH1A1TRPM8JAK2JAK1 | |
| SCHEMBL21048910 | 0.81 | PTK2 (0.40) | SLC22A12PTK2 | |
| Hydrochloric Acid SCHEMBL21048844 | 0.75 | JAK2 (0.38) | JAK2JAK1TYK2JAK3ALOX5AP | |
| SCHEMBL1291285 | 0.74 | PTK2 (0.40) | KDM4EALDH1A1GAAHTTPTK2 | |
| SCHEMBL21048809 | 0.66 | GAA (0.33) | KDM4EALDH1A1SLC22A12CYP11B1CYP11B2 | |
| SCHEMBL1626886 | 0.65 | PTK2 (0.37) | KDM4EALDH1A1GAAHTTPTK2 | |
| SCHEMBL13082590 | 0.65 | CHRNB2 (0.40) | KDM4ESLC22A12CYP11B1CYP11B2JAK3 | |
| SCHEMBL17258736 | 0.64 | PTK2 (0.36) | KDM4EALDH1A1SLC22A12GAAHTT | |
| SCHEMBL5495399 | 0.62 | KDM4E (0.41) | KDM4EALDH1A1SLC22A12CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL21048890 | 0.62 | JAK2 (0.38) | TRPM8JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |