Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 8/20 | 0.41 |
| ▸ | JAK1 | P23458 | 8/20 | 0.41 |
| ▸ | TYK2 | P29597 | 8/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048914 | 0.89 | PTK2 (0.44) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL21048880 | 0.79 | ALDH1A1 (0.48) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL16570152 | 0.76 | CYP19A1 (0.40) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL16569947 | 0.76 | ALDH1A1 (0.44) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL12409789 | 0.76 | CYP19A1 (0.40) | PTK2JAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL17258854 | 0.75 | PTK2 (0.40) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL26511945 | 0.72 | PTK2 (0.42) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL21048852 | 0.72 | ALDH1A1 (0.42) | PTK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL18754079 | 0.69 | AMY1A (0.49) | SLC6A4SLC6A3ALDH1A1NPSR1 | |
| SCHEMBL15221719 | 0.69 | SLC6A4 (0.49) | SLC6A4SLC6A3ALDH1A1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |