Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 8/20 | 0.40 |
| ▸ | JAK1 | P23458 | 8/20 | 0.40 |
| ▸ | TYK2 | P29597 | 8/20 | 0.40 |
| ▸ | JAK3 | P52333 | 8/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048804 | 0.86 | JAK2 (0.41) | ALDH1A1JAK2JAK1TYK2JAK3 | |
| SCHEMBL12280397 | 0.84 | KMT2A (0.47) | ALDH1A1PTK2KDM4ATP53HSD17B10 | |
| SCHEMBL21048880 | 0.83 | ALDH1A1 (0.48) | ALDH1A1PTK2HSPB1JAK2JAK1 | |
| SCHEMBL21048954 | 0.81 | LMNA (0.38) | JAK2JAK1TYK2JAK3KDM4A | |
| SCHEMBL5015072 | 0.79 | NPC1 (0.54) | ALDH1A1KDM4ANPSR1LMNATP53 | |
| SCHEMBL30004674 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4AGAABRD9BAZ2B | |
| SCHEMBL30005739 | 0.76 | KMT2A (0.50) | ALDH1A1GAABRD9BAZ2BBAZ2A | |
| SCHEMBL31705342 | 0.76 | KDM4A (0.44) | ALDH1A1KDM4AGAANQO2KCNA5 | |
| SCHEMBL13104124 | 0.76 | KDM4A (0.44) | JAK2JAK1KDM4AGAAKCNA5 | |
| SCHEMBL15171404 | 0.75 | NPC1 (0.52) | ALDH1A1KDM4AKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |