Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048835 | 0.87 | JAK2 (0.44) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL21048821 | 0.87 | ALDH1A1 (0.49) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL21048810 | 0.85 | GAA (0.47) | TP53NPC1RAB9AALDH1A1HTT | |
| SCHEMBL21048857 | 0.85 | HTT (0.39) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL21048804 | 0.84 | JAK2 (0.41) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL21048880 | 0.83 | ALDH1A1 (0.48) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL21048978 | 0.83 | TP53 (0.52) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL2181531 | 0.78 | NPC1 (0.46) | KMT2ANPC1RAB9AALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL21048830 | 0.77 | HTT (0.40) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL21048873 | 0.76 | JAK2 (0.46) | JAK2JAK1TYK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |