Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 4/20 | 0.33 |
| ▸ | CRY1 | Q16526 | 4/20 | 0.33 |
| ▸ | CRY2 | Q49AN0 | 4/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.33 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258804 | 0.81 | HCRTR1 (0.40) | ALDH1A1HTTUSP8USP7MAPT | |
| SCHEMBL17258915 | 0.80 | VCAM1 (0.39) | SLC22A12MEN1KMT2AEPAS1ALDH1A1 | |
| SCHEMBL6573160 | 0.79 | TRPV4 (0.36) | PTGS2EPAS1ALDH1A1HTTPTPN1 | |
| SCHEMBL21048771 | 0.78 | GLA (0.41) | MEN1KMT2AALDH1A1USP8MAPT | |
| SCHEMBL17258696 | 0.75 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1HTTPTPN1 | |
| SCHEMBL7679161 | 0.74 | KHK (0.35) | MEN1KMT2APTPN1 | |
| SCHEMBL29212553 | 0.74 | EPAS1 (0.44) | PTGS2PTGS1MEN1KMT2AEPAS1 | |
| SCHEMBL6660474 | 0.74 | KMT2A (0.36) | PTGS2PTGS1KMT2AEPAS1PER2 | |
| SCHEMBL4593998 | 0.73 | TRPV4 (0.36) | PER2CRY1CRY2 | |
| SCHEMBL31652674 | 0.71 | PTPN1 (0.36) | ALDH1A1HTTPTPN1USP8USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |