Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17258979 | 0.99 | CYP11B1 (0.52) | CYP11B1CYP11B2GAAKEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL21048941 | 0.84 | KEAP1 (0.56) | KEAP1NFE2L2PGRLMNAMAPT | |
| SCHEMBL17258875 | 0.83 | KEAP1 (0.50) | CYP11B1CYP11B2GAAKEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL17258967 | 0.81 | C5AR1 (0.40) | CYP11B1CYP11B2KEAP1NFE2L2HPGD | |
| Hydrochloric Acid SCHEMBL21048836 | 0.75 | PGR (0.56) | CYP11B1CYP11B2KEAP1NFE2L2PGR | |
| SCHEMBL26617615 | 0.72 | KDM4E (0.53) | CYP11B1CYP11B2KEAP1NFE2L2HPGD | |
| SCHEMBL30876286 | 0.72 | KEAP1 (0.56) | CYP11B1GAAKEAP1NFE2L2MAPT | |
| Hydrochloric Acid SCHEMBL21048898 | 0.71 | KEAP1 (0.46) | KEAP1NFE2L2PGRHPGDLMNA | |
| SCHEMBL29910182 | 0.69 | TAS2R14 (0.61) | KEAP1NFE2L2LMNAMAPTKDM4E | |
| SCHEMBL28773435 | 0.69 | TAS2R14 (0.61) | KEAP1NFE2L2LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |