Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | SCN1A | P35498 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21049827 | 0.91 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2USP2LMNATSHR | |
| SCHEMBL21049808 | 0.89 | LTA4H (0.46) | ALDH1A1SMN1; SMN2USP2LMNATSHR | |
| SCHEMBL21049829 | 0.85 | TSHR (0.57) | ALDH1A1SMN1; SMN2USP2LMNATSHR | |
| SCHEMBL21049830 | 0.79 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2USP2LMNATSHR | |
| SCHEMBL21049843 | 0.77 | HRH3 (0.34) | ALDH1A1SMN1; SMN2USP2LMNATSHR | |
| SCHEMBL29508217 | 0.76 | ALDH1A1 (0.88) | ALDH1A1SMN1; SMN2USP2LMNATSHR | |
| SCHEMBL19126668 | 0.76 | NPC1 (0.58) | ALDH1A1SMN1; SMN2USP2LMNATSHR | |
| SCHEMBL4404318 | 0.75 | KDM4E (0.75) | ALDH1A1SMN1; SMN2USP2LMNAMAPK1 | |
| SCHEMBL13930969 | 0.74 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2USP2LMNATSHR | |
| SCHEMBL13952296 | 0.74 | HRH3 (0.67) | ALDH1A1MAPK1CYP1A2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3707125-A1 | CAFFEIC ACID DERIVATIVES FOR TREATING HYPERPROLIFERATIVE DISEASES | Board Of Regents, The University Of Texas System (US) | 2020-09-16 | — | — | EP | disclosed |
| CN-111417625-A | Caffeic acid derivatives for the treatment of hyperproliferative diseases | 德克萨斯大学系统董事会 | 2020-07-14 | — | — | CN | disclosed |
| US-10703721-B2 | Caffeic acid derivatives and uses thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190177276-A1 | CAFFEIC ACID DERIVATIVES AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703721-B2 | Caffeic acid derivatives and uses thereof | GLS, GLS2, NCOA2 | ALDH1A1 204/4885SMN1; SMN2 3183/4885USP2 2167/4885 |
| US-20190177276-A1 | CAFFEIC ACID DERIVATIVES AND USES THEREOF | GLS, GLS2, NCOA2 | ALDH1A1 204/4885SMN1; SMN2 3183/4885USP2 2167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.