Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.48 |
| ▸ | ABAT | P80404 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 5/20 | 0.45 |
| ▸ | THRA | P10827 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14192502 | 0.87 | L3MBTL1 (0.58) | L3MBTL1ALDH1A1ALDH5A1ABATAKT1 | |
| SCHEMBL14192484 | 0.86 | GAA (0.59) | L3MBTL1ALDH1A1ALDH5A1ABATTHRB | |
| SCHEMBL5108830 | 0.84 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1PKMMAPTGAA | |
| SCHEMBL27424165 | 0.83 | THRB (0.63) | L3MBTL1ALDH1A1THRBTHRAMEN1 | |
| SCHEMBL20210968 | 0.83 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1ALDH5A1ABATAKT1 | |
| SCHEMBL6538549 | 0.80 | TP53 (0.64) | L3MBTL1THRBTHRAMEN1TP53 | |
| SCHEMBL69068 | 0.80 | GAA (0.59) | L3MBTL1PKMMAPTGAAKDM4E | |
| SCHEMBL28657555 | 0.79 | TP53 (0.67) | THRBTHRAGAAMEN1TP53 | |
| SCHEMBL30383391 | 0.79 | NPC1 (0.54) | L3MBTL1ALDH1A1ALDH5A1ABATAKT1 | |
| SCHEMBL14192482 | 0.79 | ALDH5A1 (0.52) | L3MBTL1ALDH1A1ALDH5A1ABATAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111417625-A | Caffeic acid derivatives for the treatment of hyperproliferative diseases | 德克萨斯大学系统董事会 | 2020-07-14 | — | — | CN | disclosed |
| US-10703721-B2 | Caffeic acid derivatives and uses thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190177276-A1 | CAFFEIC ACID DERIVATIVES AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703721-B2 | Caffeic acid derivatives and uses thereof | GLS, GLS2, NCOA2 | L3MBTL1 4800/4885ALDH1A1 204/4885ALDH5A1 145/4885 |
| US-20190177276-A1 | CAFFEIC ACID DERIVATIVES AND USES THEREOF | GLS, GLS2, NCOA2 | L3MBTL1 4800/4885ALDH1A1 204/4885ALDH5A1 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.