SCHEMBL21051291

SCHEMBL21051291

O=C(NCCc1cccc2ccccc12)c1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ TK1 P04183 3/20 0.52
▸ TK2 O00142 1/20 0.52
▸ LMNA P02545 2/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.50
▸ CYP1A2 P05177 1/20 0.49
▸ CYP3A4 P08684 1/20 0.49
▸ TSHR P16473 1/20 0.49
▸ BLM P54132 1/20 0.49
▸ PMP22 Q01453 1/20 0.49
▸ NPSR1 Q6W5P4 1/20 0.49
▸ ALOX12 P18054 1/20 0.48
▸ ADRA1A P35348 1/20 0.48
▸ TYMS P04818 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16373946 0.92 TK1 (0.52) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL16363404 0.92 TK1 (0.52) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL12736937 0.92 TK1 (0.52) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL19876156 0.92 TK1 (0.52) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL22015702 0.92 TK1 (0.52) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL21051287 0.87 TK1 (0.50) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL27237056 0.87 TK1 (0.50) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL21051280 0.86 TK1 (0.49) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL21051278 0.86 TK1 (0.55) TK1TK2LMNASMN1; SMN2CYP1A2
SCHEMBL21838333 0.84 TK1 (0.56) TK1TK2LMNASMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114703193-A Multiaptamer target detection 私募蛋白质体运营有限公司 2022-07-05 — — CN claimed
CN-112961860-A Aptamers that bind to IL-6 and their use in treating or diagnosing IL-6 mediated disorders 私募蛋白质体公司 2021-06-15 — — CN claimed
CN-110643610-A Nucleic acid compounds for binding complement component 3 proteins 私募蛋白质体公司 2020-01-03 — — CN claimed
US-20240218374-A1 Nucleic Acid Compounds That Bind Coronavirus Proteins SOMALOGIC OPERATING CO., INC. (US) 2024-07-04 — — US disclosed
CN-109439664-B Aptamer binding to IL-6 and use thereof in the treatment or diagnosis of IL-6 mediated disorders 私募蛋白质体操作有限公司 2024-03-08 — — CN disclosed
EP-4323374-A1 MODIFIED NUCLEOSIDES SomaLogic Operating Co., Inc. (US) 2024-02-21 — — EP disclosed
US-20230313202-A1 Oligonucleotides Comprising Modified Nucleosides SOMALOGIC OPERATING CO., INC. (US) 2023-10-05 — — US disclosed
US-11578330-B2 Oligonucleotides comprising modified nucleosides SOMALOGIC OPERATING CO., INC. (US) 2023-02-14 — — US disclosed
CN-114703193-A Multiaptamer target detection 私募蛋白质体运营有限公司 2022-07-05 — — CN disclosed
EP-3913058-A1 OLIGONUCLEOTIDES COMPRISING MODIFIED NUCLEOSIDES Somalogic, Inc. (US) 2021-11-24 — — EP disclosed
EP-3478843-B1 OLIGONUCLEOTIDES COMPRISING MODIFIED NUCLEOSIDES SOMALOGIC INC (US) 2021-08-04 — — EP disclosed
CN-112961860-A Aptamers that bind to IL-6 and their use in treating or diagnosing IL-6 mediated disorders 私募蛋白质体公司 2021-06-15 — — CN disclosed
US-20210171951-A1 Oligonucleotides Comprising Modified Nucleosides SOMALOGIC, INC. (US) 2021-06-10 — — US disclosed
US-10927380-B2 Oligonucleotides comprising modified nucleosides SOMALOGIC, INC. (US) 2021-02-23 — — US disclosed
CN-106459979-B Nucleic acid compounds for binding complement component 3 proteins 私募蛋白质体公司 2020-07-21 — — CN disclosed
CN-110643610-A Nucleic acid compounds for binding complement component 3 proteins 私募蛋白质体公司 2020-01-03 — — CN disclosed
US-20190177730-A1 Oligonucleotides Comprising Modified Nucleosides SOMALOGIC, INC. (US) 2019-06-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240218374-A1 Nucleic Acid Compounds That Bind Coronavirus Proteins SARS1, RNGTT, PABPC1 TK1 1812/4885TK2 3270/4885LMNA 1529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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