Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31372502 | 0.81 | KDM4E (0.58) | LTA4HKDM4E | |
| SCHEMBL22137693 | 0.79 | LTA4H (0.63) | HRH3LTA4HSMN1; SMN2PTGS2KDM4E | |
| SCHEMBL29615499 | 0.76 | DRD2 (0.43) | HRH3LTA4HLMNAMAPK1HTT | |
| SCHEMBL22919100 | 0.76 | DRD2 (0.43) | HRH3LTA4HLMNAMAPK1HTT | |
| SCHEMBL22584962 | 0.76 | SIGMAR1 (0.44) | HRH3SLC6A4KDM4ESLC6A2 | |
| SCHEMBL30692855 | 0.76 | SIGMAR1 (0.44) | HRH3SLC6A4KDM4ESLC6A2 | |
| SCHEMBL17198029 | 0.75 | LTA4H (0.59) | HRH3LTA4HDRD2 | |
| SCHEMBL20576384 | 0.73 | HRH3 (0.60) | HRH3MAPK1DRD2SLC6A4KDM4E | |
| SCHEMBL30692817 | 0.73 | HRH3 (0.60) | HRH3MAPK1DRD2SLC6A4KDM4E | |
| SCHEMBL82404 | 0.73 | HRH3 (0.59) | HRH3LTA4HDRD2KDM4EPSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111406054-B | 1,2, 4-oxadiazole derivatives as inhibitors of histone deacetylase 6 | 奥莱松基因组股份有限公司 | 2024-01-02 | — | — | CN | disclosed |
| US-20230026909-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS | ORYZON GENOMICS, S.A. (ES) | 2023-01-26 | — | — | US | disclosed |
| US-20200339569-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS | ORYZON GENOMICS, S.A. (ES) | 2020-10-29 | — | — | US | disclosed |
| EP-3720851-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS | Oryzon Genomics, S.A. (ES) | 2020-10-14 | — | — | EP | disclosed |
| CN-111406054-A | 1, 2, 4-oxadiazole derivatives as inhibitors of histone deacetylase 6 | 奥莱松基因组股份有限公司 | 2020-07-10 | — | — | CN | disclosed |
| WO-2019110663-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS | ORYZON GENOMICS, S.A. (ES) | 2019-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339569-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS | HDAC6, HDAC1, HDAC3 | HRH3 507/4885LTA4H 2792/4885LMNA 3578/4885 |
| US-20230026909-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS | HDAC6, HDAC1, HDAC3 | HRH3 507/4885LTA4H 2792/4885LMNA 3578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.