Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 4/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898174 | 0.87 | TRIM58 (0.56) | KDM4ELMNAALDH1A1MAPTTRIM58 | |
| SCHEMBL21055786 | 0.86 | LMNA (0.44) | KDM4ELMNAALDH1A1MAPTHRH4 | |
| SCHEMBL10925980 | 0.85 | LMNA (0.54) | KDM4ELMNAALDH1A1MAPTHTT | |
| SCHEMBL3598923 | 0.84 | HTR3A (0.57) | ALDH1A1TRIM58HTR3AHRH4HTT | |
| SCHEMBL21055793 | 0.83 | HTT (0.60) | KDM4ELMNAALDH1A1MAPTTRIM58 | |
| SCHEMBL14690661 | 0.81 | LMNA (0.50) | KDM4ELMNAALDH1A1MAPTHTT | |
| SCHEMBL21055792 | 0.79 | APP (0.48) | KDM4ELMNAALDH1A1MAPT | |
| SCHEMBL30014145 | 0.78 | KDM4E (0.62) | KDM4ELMNAALDH1A1MAPTHTT | |
| SCHEMBL1993196 | 0.78 | KDM4E (0.62) | KDM4ELMNAALDH1A1MAPTHTT | |
| SCHEMBL21055799 | 0.77 | PDE5A (0.69) | KDM4ELMNAALDH1A1MAPTHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10323007-B1 | N2N N4-disubstituted quinazoline-2,4-diamines and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2019-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10323007-B1 | N2N N4-disubstituted quinazoline-2,4-diamines and uses thereof | NQO2, NQO1, NIT2 | KDM4E 1608/4885LMNA 767/4885ALDH1A1 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.