Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | C1R | P00736 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21055797 | 0.86 | KDM4E (0.55) | LMNAKDM4EALDH1A1MAPTHRH4 | |
| SCHEMBL21055788 | 0.84 | HRH4 (0.57) | KDM4EALDH1A1MAPTHRH4PDE2A | |
| SCHEMBL21055785 | 0.81 | PTGES (0.47) | HRH4PDE2AACHECYP1A2CYP3A4 | |
| SCHEMBL30013659 | 0.78 | ALDH1A1 (0.49) | LMNAKDM4EALDH1A1MAPTC1R | |
| SCHEMBL183983 | 0.78 | ALDH1A1 (0.49) | LMNAKDM4EALDH1A1MAPTC1R | |
| SCHEMBL8898174 | 0.78 | TRIM58 (0.56) | LMNAKDM4EALDH1A1MAPTHRH4 | |
| SCHEMBL1622223 | 0.77 | CYP1A2 (0.61) | LMNAKDM4EALDH1A1MAPTCYP1A2 | |
| SCHEMBL11609819 | 0.75 | HTT (0.50) | LMNAKDM4EALDH1A1MAPTHRH4 | |
| SCHEMBL3598923 | 0.74 | HTR3A (0.57) | ALDH1A1HRH4PDE2AMAT2A | |
| SCHEMBL3115102 | 0.72 | HTT (0.56) | LMNAHRH4CTNNB1TCF7L2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10323007-B1 | N2N N4-disubstituted quinazoline-2,4-diamines and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2019-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10323007-B1 | N2N N4-disubstituted quinazoline-2,4-diamines and uses thereof | NQO2, NQO1, NIT2 | LMNA 767/4885KDM4E 1608/4885ALDH1A1 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.