Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20492672 | 0.89 | MEN1 (0.48) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MEN1 | |
| SCHEMBL21063795 | 0.85 | MAPT (0.43) | SMN1; SMN2MAPTMEN1KMT2ATP53 | |
| SCHEMBL28342305 | 0.82 | TDP1 (0.42) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL20492781 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MAPK1 | |
| SCHEMBL6766529 | 0.81 | RAB9A (0.54) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MAPK1 | |
| SCHEMBL24240443 | 0.81 | MEN1 (0.49) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MEN1 | |
| SCHEMBL28339795 | 0.76 | HPGD (0.49) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL20492552 | 0.76 | DRD2 (0.42) | ALDH1A1MEN1KMT2ALMNAABCB1 | |
| SCHEMBL20492724 | 0.73 | HPGD (0.49) | ALDH1A1SMN1; SMN2MAPTL3MBTL1MEN1 | |
| SCHEMBL20841157 | 0.72 | HPGD (0.43) | ALDH1A1SMN1; SMN2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724222-A1 | ANTIBODY CONSTRUCT-DRUG CONJUGATE FOR THE TREATMENT OF HEPATITIS | Silverback Therapeutics, Inc. (US) | 2020-10-21 | — | — | EP | disclosed |
| WO-2019118884-A1 | ANTIBODY CONSTRUCT-DRUG CONJUGATE FOR THE TREATMENT OF HEPATITIS | SILVERBACK THERAPEUTICS, INC. (US) | 2019-06-20 | — | — | WO | disclosed |