Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114686 | 0.77 | ALDH1A1 (0.46) | NPC1RAB9AHSD17B10ALDH1A1HTT | |
| SCHEMBL28335753 | 0.72 | ALDH1A1 (0.59) | NPC1RAB9AHSD17B10ALDH1A1HTT | |
| SCHEMBL242843 | 0.70 | HSD17B10 (0.55) | NPC1RAB9AHSD17B10ALDH1A1HTT | |
| SCHEMBL8122573 | 0.70 | POLB (0.63) | NPC1RAB9AALDH1A1HTT | |
| SCHEMBL21261732 | 0.70 | HSD17B10 (0.58) | NPC1RAB9AHSD17B10ALDH1A1HTT | |
| SCHEMBL5108159 | 0.69 | NPC1 (0.69) | NPC1RAB9AHSD17B10ALDH1A1HTT | |
| SCHEMBL4677107 | 0.69 | MEN1 (0.58) | NPC1RAB9AHSD17B10ALDH1A1HTT | |
| SCHEMBL241820 | 0.68 | HSD17B10 (0.49) | NPC1RAB9AHSD17B10ALDH1A1HTT | |
| SCHEMBL21925516 | 0.67 | HSD17B10 (0.54) | NPC1RAB9AHSD17B10ALDH1A1HTT | |
| SCHEMBL126140 | 0.67 | HSD17B10 (0.54) | NPC1RAB9AHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308666-B2 | 7-aminocephem derivative compounds | MERCK SHARP & DOHME CORP. (US) | 2019-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308666-B2 | 7-aminocephem derivative compounds | AAAS, ALAD, NPEPPS | NPC1 2262/4885RAB9A 1072/4885HSD17B10 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.