Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27661804 | 0.82 | TRPV1 (0.41) | ALDH1A1HSD17B10MAPTGAAKDM4E | |
| SCHEMBL17853274 | 0.78 | CNR2 (0.34) | ALDH1A1MAPTKDM4ECYP1A2KMT2A | |
| SCHEMBL21064489 | 0.77 | NPC1 (0.45) | ALDH1A1HSD17B10HTTNPC1RAB9A | |
| SCHEMBL617561 | 0.77 | TRPV1 (0.52) | ALDH1A1MAPTTRPV1NPSR1KMT2A | |
| SCHEMBL3105963 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HSD17B10MAPTGAAKDM4E | |
| SCHEMBL5497757 | 0.77 | BRD9 (0.36) | CYP1A2KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL10424370 | 0.72 | NPC1 (0.57) | ALDH1A1MAPTGAAKDM4EHPGD | |
| SCHEMBL24756637 | 0.72 | F2 (0.48) | ALDH1A1MAPTGAAKDM4EGLA | |
| SCHEMBL15890215 | 0.71 | ALDH1A1 (0.55) | ALDH1A1MAPTGAAKDM4ENPSR1 | |
| SCHEMBL4330122 | 0.71 | KMT2A (0.47) | ALDH1A1MAPTGAAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180170949-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2018-06-21 | — | — | US | disclosed |
| US-20170362183-A1 | PYRAZOLYL CARBOXYLIC ACID AND PYRAZOLYL UREA DERIVATIVE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-12-21 | — | — | US | disclosed |
| US-20160176897-A1 | 7-AMINOCEPHEM DERIVATIVE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2016-06-23 | — | — | US | disclosed |
| EP-1556389-B9 | CEPHEM COMPOUNDS | ASTELLAS PHARMA INC (JP) | 2015-09-09 | — | — | EP | disclosed |
| EP-1556389-B3 | CEPHEM COMPOUNDS | ASTELLAS PHARMA INC (JP) | 2015-04-01 | — | — | EP | disclosed |
| EP-1663245-B1 | CEPHEM COMPOUNDS | ASTELLAS PHARMA INC (JP) | 2010-04-07 | — | — | EP | disclosed |
| EP-1556389-B1 | CEPHEM COMPOUNDS | ASTELLAS PHARMA INC (JP) | 2007-07-25 | — | — | EP | disclosed |
| US-7192943-B2 | Cephem compounds | ASTELLAS PHARMA INC. (JP) | 2007-03-20 | — | — | US | disclosed |
| US-20070037786-A1 | Cephem compounds | WAKUNAGA PHARMACEUTICAL CO., LTD. (JP) | 2007-02-15 | — | — | US | disclosed |
| US-7129232-B2 | For therapy of of infectious diseases | ASTELLAS PHARMA INC. (JP) | 2006-10-31 | — | — | US | disclosed |
| EP-1663245-A1 | CEPHEM COMPOUNDS | Astellas Pharma Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
| US-20050096306-A1 | Cephem compounds | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-05-05 | — | — | US | disclosed |
| WO-2005027909-A1 | CEPHEM COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2005-03-31 | — | — | WO | disclosed |
| US-20040132994-A1 | Cephem compounds | FUJISAWA PHARMACEUTICAL CO., LTD (JP) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037786-A1 | Cephem compounds | CEP170, ABCB11, SLC7A1 | ALDH1A1 1158/4885HSD17B10 207/4885MAPT 2537/4885 |
| US-20040132994-A1 | Cephem compounds | CEP170, ABCB11, RCC2 | ALDH1A1 908/4885HSD17B10 145/4885MAPT 3238/4885 |
| US-20180170949-A1 | SYNTHESIS OF CEPHALOSPORIN COMPOUNDS | COASY, MRPL21, CHLSN | ALDH1A1 2750/4885HSD17B10 707/4885MAPT 3979/4885 |
| US-20160176897-A1 | 7-AMINOCEPHEM DERIVATIVE COMPOUNDS | AAAS, ALAD, NPEPPS | ALDH1A1 2566/4885HSD17B10 1283/4885MAPT 4018/4885 |
| US-20170362183-A1 | PYRAZOLYL CARBOXYLIC ACID AND PYRAZOLYL UREA DERIVATIVE COMPOUNDS | UROD, PEPD, CMPK1 | ALDH1A1 1669/4885HSD17B10 3525/4885MAPT 1190/4885 |
| US-20050096306-A1 | Cephem compounds | CEP170, ASS1, C1S | ALDH1A1 1854/4885HSD17B10 386/4885MAPT 3569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.