Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 3/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SPR | P35270 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13249922 | 0.69 | KMT2A (0.41) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL21064517 | 0.66 | GPBAR1 (0.53) | TYMSMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6848735 | 0.65 | TSHR (0.49) | ADORA2AADORA1MAPTKMT2ASPR | |
| SCHEMBL6848943 | 0.65 | TSHR (0.57) | ADORA2AADORA1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21003097 | 0.63 | ADORA2A (0.41) | ADORA2AADORA1SPRPARP1HPGD | |
| SCHEMBL23973185 | 0.63 | MTHFD2 (0.42) | MAPTSPRCYP3A4 | |
| SCHEMBL721339 | 0.61 | SLC6A5 (0.58) | SMN1; SMN2MEN1KMT2AKDM4EBLM | |
| SCHEMBL13249856 | 0.58 | PTGDR2 (0.38) | KMT2ALMNA | |
| SCHEMBL10568181 | 0.57 | HPGD (0.53) | TYMSMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8360518 | 0.57 | PARP1 (0.56) | CDK4CCND1PARP1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308656-B2 | Small molecule inhibitors of Ku70/80 and uses thereof | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2019-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308656-B2 | Small molecule inhibitors of Ku70/80 and uses thereof | XRCC6, XRCC5, RAD50 | ADORA2A 4705/4885ADORA1 4772/4885TYMS 943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.